Clinical Evaluation of Serum Alpha Feto-Protein (AFP) and Interlukin-6 in Hepatocellular Carcinoma
S.S. Haque
Department of clinical Biochemistry, Indira Gandhi Institute of Medical Sciences, Patna-14, India
Bandana Kumari
Department of clinical Biochemistry, Indira Gandhi Institute of Medical Sciences, Patna-14, India
M.A. Muzaffar
Department of Pathology, Indira Gandhi Institute of Medical Sciences, Patna-14, India
Rekha Kumari
Department of clinical Biochemistry, Indira Gandhi Institute of Medical Sciences, Patna-14, India
U. Kuma
Department of clinical Biochemistry, Indira Gandhi Institute of Medical Sciences, Patna-14, India
A Saran
Department of clinical Biochemistry, Indira Gandhi Institute of Medical Sciences, Patna-14, India
Md. Tanweeruddin
Department of Anaesthesiology, ECR, Danapur, India
Pawan Kumar
Department of Radiology, Darbhanga Medical College Darbhanga, India
Keywords: AFP, HCC, IL-6.
Abstract
Background: Hepatocellular carcinoma (HCC) is one of the important cancers worldwide and predominant in Asia and Africa. A number of evidence suggests a possible role of interleukin-6 (IL-6) and α-Fetoprotein (AFP) in the pathogenesis of hepatocellular carcinoma (HCC).
Patients and methods: We studied both IL-6 and AFP in patients with HCC or in healthy controls. Serum IL-6, AFP was measured by enzyme linked immunosorbent assay and Chemiluminescent immunoassay respectively in 30 patients with primary hepatocellular carcinoma and 30 normal subjects
Results:IL-6 and AFP was found in high levels in the serum of patients initially diagnosed with HCC (18±9.8), and (315.99±594.62) respectively compared with healthy subjects (4.29±2.10).and (3.13±1.27).A significant positive correlation was found between mean levels of IL- 6 & AFP in HCC (P < 0.05), Combination of IL-6 and AFP improved the sensitivity in diagnosing HCC or predicting future HCC development. Conclusions: IL-6 along with AFP could be considered a promising tumor marker for HCC. In particular, the diagnostic value of the test is significantly increased when combined with AFP.