Published
2019-06-20
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Articles
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Behavioral, Neurochemical and Histological Changes in the Use of Low Doses of Naltrexone and Donepezil in the Treatment in Experimental Model of Alzheimer’s Disease by Induction of β-Amyloid1-42 in Rats
Felipe Carmo de Moura
Superior Institute of Biomedical Science, Ceara State University, Fortaleza, Ceara, Brazil.
https://orcid.org/0000-0003-4476-6393
Marluy Kildary Fernandes Xavier
Ceara Estacio Center University, Brazil.
https://orcid.org/0000-0001-8231-8431
Francisca Eliane Lima Rodrigues
State University Vale do Acarau, Brazil.
http://orcid.org/0000-0001-5378-5719
Marcos Fabio dos Santos Pinheiro
Faculty of Medicine, Federal University of Ceara, Brazil.
https://orcid.org/0000-0002-0128-1276
Erika Clemente Lima Machado
Ceara Estacio Center University, Brazil.
Caricia Bianca Carmo de Moura
Faculty of Medicine, Federal University of Ceara, Brazil.
https://orcid.org/0000-0002-5038-7835
Wilson Max Almeida Monteiro de Moraes
Post-Graduation Program on Physical Education, Catholic University of Brasilia (UCB), Brasília, Federal District, Brazil.
https://orcid.org/0000-0001-5155-3535
Jonato Prestes
Post-Graduation Program on Physical Education, Catholic University of Brasilia (UCB), Brasília, Federal District, Brazil.
http://orcid.org/0000-0003-0399-8817
Edna Maria Camelo Chaves
Superior Institute of Biomedical Science, Ceara State University, Fortaleza, Ceara, Brazil.
https://orcid.org/0000-0001-9658-0377
DOI: https://doi.org/10.20448/journal.510.2019.61.5.13
Keywords: Alzheimer’s disease, β-amyloid1-42, Naltrexone, Neurochemical, Behaviour, Histological changes.
Abstract
Alzheimer's disease (AD) is a progressive neurodegenerative disorder that promotes the involvement of memory-related functions, characterized by the presence of amyloid plaques formed by the β-amyloid peptide (Aβ), and hyperphosphorylated Tau protein neurofibrillary tangles. Evidence suggests that the use of low doses of Naltrexone, an opioid antagonist, possibly promotes a modulation of the immune system and consequent neuroprotective effect. The present study uses the animal model of induction with β-amyloid1-42 (Aβ1-42) to verify the behavioral, neurochemical and histological effects of the use of low doses of Naltrexone. Male wistar rats (250-300g) divided into five groups (N = 8) were used: Control, Sham, Aβ1-42 subdivided into three groups: treated with water, 05 mg Donepezil and 4.5 mg Naltrexone, orally during the 30-day period. Behavioral tests demonstrated the efficacy of induction to the experimental model with reduced memory of Aβ1-42-treated animals as well as reversal of damage in animals treated with Naltrexone. In the structural analysis, observed that the animals induced by Aβ1-42 treated with water alone presented alterations in the pyramidal forms of the hippocampal cells and that the animals treated with Naltrexone presented possibly a reversal of the neuronal damages. In conclusion, treatment with Naltrexone promoted a reversal in the memory impairment of rodents induced to the Alzheimer's model with Aβ1-42 in the behavioral and histological response.