Published
2019-07-24
Issue
Section
Articles
How to Cite
Antidiabetic and Antihyperlipidemic Effects of Aqueous Extract of Carica papaya Leaf on the Experimental Model against Single Alloxan Toxicity
Ukpabi C.F.
Department of Biochemistry, Abia State Polytechnic, Aba, Nigeria
https://orcid.org/0000-0001-6092-3673
Chukwu M.N
Department of Biochemistry and Department of Food Technology Abia State Polytechnic, Aba, Nigeria
https://orcid.org/0000-0003-3371-7983
Onyemaechi, J.N.
Department of Chemistry, Abia State Polytechnic, Aba, Nigeria
https://orcid.org/0000-0002-8336-8657
Ibe P
Department of Chemistry, Abia State Polytechnic, Aba, Nigeria
https://orcid.org/0000-0002-4220-949X
Onuh E.F.
Department of Chemistry, Abia State Polytechnic, Aba, Nigeria
https://orcid.org/0000-0001-9959-2840
DOI: https://doi.org/10.20448/journal.510.2019.61.14.18
Keywords: Carica papaya, Phytochemicals, Antidiabetic, hyperlipidemia activities, Lipoproteins, hyperglycermia
Abstract
Antidiabetic and antihyperlipidemic effects of aqueous extract of Carica papaya leaf on the toxicity were investigated. A total of thirty rats were divided into six groups of 5 rats: Group A: Normal control, Group B: Negative control, Group C: Positive control I, Group D: Positive control II, Group E: Test control I, Group F: Test control II. Diabetes was induced with a single dose of alloxan (120mg/kg) body weight and serum glucose was taken 72hrs after induction to confirm diabetes. The oral administration for hyperglycemia and hyperlipidemia started on the 4th and 8th day of the experiment respectively. The result showed that Carica papaya leaf extract significantly and progressively lowered the glucose level, TG, TC and LDL dose dependently while significantly causing a dose-related elevation in HDL concentration when compared to the untreated control and positive control groups (I & II) treated rats. Phytochemical analysis revealed the presence of alkaloids, flavonoids, saponins and tannins. The aqueous extract of this plant can be used to brew a tonic that will allay the metabolic disruption produced by diabetes.