Published
2018-12-18
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Articles
How to Cite
Assessment of the Secondary Metabolite Patulin and Lycium Barbarum Fruit on INS-1 Rat Pancreatic Β-Cells
Madeha N. Al-Seeni
Biochemistry Department, Faculty of Science, King Abdel-Aziz University, Jaddah, Saudi Arabia.
Ahmed M. Ali
Chemistry department, faculty of science, Al –Azhar University, Assiut Branch, Egypt
Nagwa M. Elsawi
Chemistry Department, Faculty of Science, Sohag University, Sohag, Egypt
Asma S. Abdo
Chemistry Department, Faculty of Science, Sohag University, Sohag, Egypt
DOI: https://doi.org/10.20448/journal.512.2017.41.24.29
Keywords: Patulin, Pancreas, Goji extract, Insulin.
Abstract
Patulin has been shown to have diabetogenic effects in mice. The effects on pancreatic β-cell viability and function of secondary metabolite patulin were investigated. Using forty adult albino male rats which divided into 4 groups. Control group was injected subcutaneously daily with distilled water for one week; group I was injected subcutaneously daily with Patulin (0.2 mg/kg/day) for two weeks. Group II was injected with the same toxin and dose for two weeks after that they were treated by Goji extract (2 ml/kg /day.) for two weeks. Group III was treated by Goji for two weeks after that they were injected with patulin for two weeks. Some biochemical parameters of blood samples for experimental rodents were evaluated. Patulin group shows significant increase in amylase and glucose levels. But level of C-peptide and Insulin decreased significantly in this group. However, there is no significant alteration in Lipase level between patulin group and control. Groups treated with goji extract in groups two and three (therapeutic and prophylactic) illustrated non significant alteration in biochemical parameters compared to control.